DMT is an illegal, psychedelic compound found in the human body and at least 60 species of plants worldwide. Terence McKenna (who has raised awareness of DMT to its present level) called DMT “the most powerful hallucinogen known to man and science” in his 1994 lecture Rap Dancing Into the Third Millennium

McKenna first smoked DMT as an undergraduate at Berkeley in early 1967. He had experience with LSD—ingesting it “once a month or so”—and other psychedelics, but said in an interview:

It was really the DMT that empowered my commitment to the psychedelic experience.

DMT was so much more powerful, so much more alien, raising all kinds of issues about what is reality, what is language, what is the self, what is three-dimensional space and time, all the questions I became involved with over the next twenty years or so. – Terence McKenna, The Archaic Revival (1992)

Third Eye Perception

From 1990 to 1995, Dr. Rick Strassman administered 400 intravenous doses of DMT to 60 heavily pre-screened volunteers with extensive experience with psychedelics. He documented the results—in fascinating detail, because it “was important that other people knew how to wind their way through this maze,” the two-year process was published in DMT: The Spirit Molecule (Dec 2000), nine months after Terence McKenna died.

The pineal gland of older life forms, like lizards, is called “the ‘third’ eye” and has a lens, cornea, and retina. As life evolved, the pineal moved deeper into the brain. The human pineal gland is not actually part of the brain. Rather, it develops from specialized tissues in the roof of the fetal mouth. From there it migrates to the center of the brain, where it seems to have the best seat in the house.

Twenty-five years ago, Japanese scientists discovered that the brain actively transports DMT across the blood-brain barrier into its tissues. I know of no other psychedelic drug that the brain treats with such eagerness.

This is a startling fact that we should keep in mind when we recall how readily biological psychiatrists dismissed a vital role for DMT in our lives.

If DMT were only an insignificant, irrelevant by-product of our metabolism, why does the brain go out of its way to draw it into its confines? – Dr. Rick Strassman, DMT Researcher

DMT: You cannot imagine a stranger drug or experience  | VICE